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1. Moby Thesaurus II by Grady Ward, 1.0
Herculean, adverse, aggravating, alarming, annoying, antagonistic, arduous, awkward, backbreaking, besetting, bothering, bothersome, burdensome, chafing, choking, clumsy, conflicting, constrictive, contrary, counter, counteractive, counterproductive, crosswise, crushing, detrimental, difficult, discommodious, disquieting, distressful, distressing, disturbing, effortful, exasperating, forced, fretting, galling, grueling, harassing, hard, hard-earned, hard-fought, harmful, heavy, hefty, hindering, hindersome, hostile, importunate, importune, in opposition, in the way, incommodious, inconvenient, infestive, inhibiting, inhibitive, inimical, interrupting, interruptive, irking, irksome, irritating, killing, labored, laborious, mean, miserable, not easy, obstructing, obstructive, obstruent, occlusive, onerous, operose, opposed, opposing, opposite, oppressive, painful, pesky, pestering, pestiferous, pestilent, pestilential, plaguesome, plaguey, plaguing, provoking, punishing, repressive, restrictive, rigorous, sinister, stifling, strained, strangling, strenuous, stressful, suppressive, teasing, tiresome, toilsome, tormenting, tough, troubling, troublous, trying, ugly, unfavorable, unhandy, untoward, unwieldy, uphill, upsetting, vexatious, vexing, wearisome, wicked, worrisome, worrying, wretched
Dictionary Results for troublesome:
1. WordNet® 3.0 (2006)
troublesome
    adj 1: difficult to deal with; "a troublesome infection"; "a
           troublesome situation"

2. The Collaborative International Dictionary of English v.0.48
Troublesome \Trou"ble*some\, a.
   Giving trouble or anxiety; vexatious; burdensome; wearisome.
   [1913 Webster]

         This troublesome world.                  --Book of
                                                  Common Prayer.
   [1913 Webster]

         These troublesome disguises that we wear. --Milton.
   [1913 Webster]

         My mother will never be troublesome to me. --Pope.
   [1913 Webster]

   Syn: Uneasy; vexatious; perplexing; harassing; annoying;
        disgusting; irksome; afflictive; burdensome; tiresome;
        wearisome; importunate.
        [1913 Webster] -- Trou"ble*some*ly, adv. --
        Trou"ble*some*ness, n.
        [1913 Webster]

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