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1. Moby Thesaurus II by Grady Ward, 1.0
acerb, acerbate, acerbic, acid, acidic, acidulent, acidulous, acrimonious, adrenal, bearish, bitchy, bitter, blase, burning, cankered, cantankerous, caustic, choleric, churlish, crabbed, cranky, cross, cross-grained, crusty, cussed, disagreeable, dispirited, eccrine, embittered, endocrine, excitable, exocrine, fed-up, feisty, fractious, glandular, glandulous, gonadal, good and tired, holocrine, huffish, huffy, humoral, irascible, irked, irritable, jaded, life-weary, luteal, mean, melancholic, melancholy, merocrine, ornery, ovarian, pancreatic, perverse, prostatic, rancorous, rankled, resentful, resenting, satiated, sick, sick of, snappish, sore, spiteful, spleeny, stewing, testy, thymic, thyroidal, tired, tired of, tired of living, tired to death, ugly, virulent, waspish, wearied, weariful, weary, weary unto death, world-weary
Dictionary Results for splenetic:
1. WordNet® 3.0 (2006)
    adj 1: of or relating to the spleen [syn: splenic,
           splenetic, lienal]
    2: very irritable; "bristly exchanges between the White House
       and the press"; "he became prickly and spiteful"; "witty and
       waspish about his colleagues" [syn: bristly, prickly,
       splenetic, waspish]

2. The Collaborative International Dictionary of English v.0.48
Splenetic \Splen"e*tic\, a. [L. spleneticus: cf. F.
   spl['e]n['e]tique. See Spleen.]
   Affected with spleen; malicious; spiteful; peevish; fretful.
   "Splenetic guffaw." --G. Eliot.
   [1913 Webster]

         You humor me when I am sick;
         Why not when I am splenetic?             --Pope.
   [1913 Webster]

   Syn: Morese; gloomy; sullen; peevish; fretful.
        [1913 Webster]

3. The Collaborative International Dictionary of English v.0.48
Splenetic \Splen"e*tic\, n.
   A person affected with spleen.
   [1913 Webster]

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