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1. Moby Thesaurus II by Grady Ward, 1.0
aching heart, affliction, agony, agony of mind, anguish, bale, bitterness, bleeding heart, broken heart, brokenheartedness, care, crushing, depression, depth of misery, desolation, despair, dole, extremity, grief, heartbreak, heartbrokenness, heartsickness, heartsoreness, heavy heart, infelicity, melancholia, melancholy, misery, prostration, regret, rue, sadness, suicidal despair, woe, wretchedness
Dictionary Results for heartache:
1. WordNet® 3.0 (2006)
heartache
    n 1: intense sorrow caused by loss of a loved one (especially by
         death) [syn: grief, heartache, heartbreak,
         brokenheartedness]

2. The Collaborative International Dictionary of English v.0.48
Heartache \Heart"ache`\ (-[=a]k`), n. [Cf. AS. heortece.]
   Sorrow; anguish of mind; mental pang. --Shak.
   [1913 Webster]

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